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KMID : 0381920100400010029
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Korean Journal of Microscopy
2010 Volume.40 No. 1 p.29 ~ p.35
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Protective Effect of Lithospermum erythrorhizon on Galactosamine Induced Liver Injury
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Lee Hyun-Hwa
Song Seon-Young
Yoon Jung-Sik
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Abstract
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The present study was carried out to investigate the hepatoprotective effect of water extract of Lithospermum erythrorhizon on acute hepatotoxicity induced in Sprague-Dawley (SD) rats by a single dose of galactosamine (400 mg/kg, i.p). The animals were divided into four groups. The animals in the Con group were fed basal diet. GalN group were administered with galactosamine. LE200 and LE500 groups treated with water extract of Lithospermum erythrorhizon (such as 200 and 500 mg/kg/day, p.o) for 7 days before galactosamine injection. In the change of AST, ALT, ALP, GGT and LDH contents, as compared with GalN group, LE200 group were significantly decreased. According to the electron microscopical observation, liver cells were increased the lipid droplet, change of mitochondria in the GalN compared with LE200. These results suggest that administration of water extract of Lithospermum erythrorhizon suppress or retard galactosamine induced acute liver injury.
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KEYWORD
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ALP, ALT, Galactosamine, GGT, Lithospermum erythrorhizon, liver injury
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